Brenner and rectors the kidney pdf
Brenner and Rector's The Kidney, 8th Edition - PDF Free DownloadAccustomed to managing diabetes with agents that mostly act by modulating the secretion and actions of insulin, with the advent of sodium-glucose linked transporter-2 SGLT-2 inhibitors, physicians are now aware that the kidney also needs to be considered in the spectrum of action of anti-hyperglycaemic agents. Though familiar with the need for dose adjustment when prescribing many of our current anti-hyperglycaemic drugs in the setting of kidney dysfunction, with the SGLT-2 inhibitors pharmacodynamic as well as pharmacokinetic aspects also need to be considered. Finally, through their ability to reduce intraglomerular pressure, systemic blood pressure and plasma uric acid concentration, the SGLT-2 inhibitors offers the possibility of kidney protection. The ability of sodium-glucose linked transporter-2 SGLT-2 inhibitors to lower plasma glucose in subjects with diabetes and kidney disease as well as their potential for kidney protection seem directly related to the perturbations in kidney physiology that they induce. Here, we review the mechanisms underlying the altered efficacy of SGLT-2 inhibitors in the setting of chronic kidney disease CKD , the propensity for some of the adverse events associated with their use along with the theoretical basis for their potential to afford kidney protection. Glucose in plasma is filtered freely at the glomerulus but is subsequently completely reabsorbed in the proximal tubule until its maximal reabsorptive capacity Tm G is exceeded. Though both fasting and two-hour postprandial glucose concentrations are well below this threshold in healthy subjects, glucose concentrations may transiently rise above it shortly after a meal such that a small amount of glucose 3.
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Physiology and Pathophysiology of the Aging Kidney Your request to send this item has been completed. National Kidnet for Biotechnology InformationU? Each chapter begins with an overview, which makes finding information very simple.
Urinary Stone Disease Since intraglomerular hypertension is thought to be a key factor in the pathogenesis of many forms of CKD, strategies that reduce intraglomerular pressure may be renoprotective. Table 1. This helps to highlight material and allow distinctions between section headings and charts.
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Renal Acidification Mechanisms Renovascular Hypertension and Ischemic Nephropathy Secondary Glomerular Disease Kidney -- physiopathology. The heavy weight of the two volumes may, however.
The field of nephrology continues to expand, particularly in the areas of dialysis techniques and transplantation. This expansion has resulted in the mushrooming of textbooks addressing these areas. This textbook not only complements Brenner's text by expanding on the topics discussed there but can also stand alone as a textbook on chronic kidney disease CKD , dialysis, and transplantation. It has been increasingly recognized that as many as 20 million Americans have some degree of CKD. Earlier intervention and management of patients with CKD by both primary care physicians and nephrologists can help slow the progression of renal disease. Pereira et al have introduced several new chapters into their text focusing on the unique problems associated with managing patients with CKD.
The E-mail message field is required. You have entered an invalid code. Pathophysiology of Proteinuria As detailed in the prescribing information, kidney function should be assessed prior to starting patients on an SGLT-2 inhibitor and measured periodically thereafter!
Add a review and share your thoughts with other readers. Transplantation Immunobiology The inclusion of up to literature references per chapter may iidney questioned, although we recognize that this choice guarantees a high degree of reliability by precise literature citations. Sign In or Create an Account.
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